Characterization and distribution of collagen types in arterial heterografts originating from the calf carotis.

The immunohistochemical results showed that the distribution of the collagen types in calf carotis is the same as that found in human arteries. Mechanically prepared and ficin-treated vessels showed a removal of cells, elastic fibres and type II collagen. The remaining collagen meshwork was shown by immunohistochemical methods and also by amino acid analysis to be type I collagen. Because of its structural, chemical and immunological properties, the protease treated, aldehyde stabilised Arteria carotis communis of the calf is suitable as a replacement material for arterial segments. Initial successes using man as a recipient support the stated conclusion.