Monahan C M, Chapman M R, French D D, Klei T R
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge.
J Parasitol. 1995 Feb;81(1):117-8.
During a series of dose-titration experiments designed to evaluate the efficacy of moxidectin oral gel against equine gastrointestinal parasites, infection with Onchocerca cervicalis was diagnosed in 25 of 82 ponies prior to treatment. Microfilariae were identified in full-thickness skin biopsies taken from the ventral midline. Treatment with moxidectin in single doses of 300, 400, or 500 micrograms/kg of body weight was 100% effective in eliminating microfilariae from 20 skin biopsies taken 14 days posttreatment, whereas 5 microfilaria-positive ponies in 2 control groups remained positive following placebo treatment. No adverse reaction was seen in any pony following treatment with moxidectin or the vehicle control.
在一系列旨在评估莫西菌素口服凝胶对马胃肠道寄生虫疗效的剂量滴定实验中，82匹小马在治疗前有25匹被诊断感染了颈盘尾丝虫。在取自腹中线的全层皮肤活检中发现了微丝蚴。以300、400或500微克/千克体重的单剂量莫西菌素治疗，在治疗后14天从20份皮肤活检中清除微丝蚴的效果达100%，而2个对照组中的5匹微丝蚴阳性小马在接受安慰剂治疗后仍为阳性。用莫西菌素或赋形剂对照治疗后，任何一匹小马均未出现不良反应。
