Miyakawa T, Yagi T, Watanabe S, Niki H
Department of Psychology, Faculty of Letters, University of Tokyo, Japan.
Brain Res Mol Brain Res. 1994 Nov;27(1):179-82. doi: 10.1016/0169-328x(94)90201-1.
Fyn-deficient mice were produced by inserting the beta-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.
通过将β-半乳糖苷酶基因（lacZ）插入Fyn基因座来培育Fyn基因缺陷型小鼠。与杂合Fyn基因缺陷型（+/fynz）小鼠相比，纯合Fyn激酶缺陷型（fynz/fynz）小鼠在明暗选择试验中表现出更强的避光性，在新奇偏好试验和被动回避试验中具有更高的恐惧反应得分。这些结果表明，fynz/fynz小鼠对诱发恐惧的刺激反应过度。
