Shliakhtenko L I, Kryga L N, Aleĭnik M D, Vasil'eva V I, Mukomolov S L, Rumovskiĭ V I, Shargorodskaia E P, Asratian A A, Bystrova T N
Zh Mikrobiol Epidemiol Immunobiol. 1994 Sep-Oct(5):42-5.
For the first time population immunity to virus hepatitis A has been studied during three different phases of prolonged morbidity cycles of this infection, and the results of this study have been compared with the data on morbidity in different age groups. Pronounced variability of the immunological structure of the population in different age groups, found to be related to the dynamics of hepatitis A morbidity, has been established. Fluctuations in immunity level are most pronounced among children aged 1-6 and 7-14 years, having the least proportion of seropositive persons. A new epidemic cycle is started among these groups of the population, and at the first stage this cycle is manifested by an increase in the intensity of the latently developing epidemic process. This is followed by the activation of registered morbidity among the whole of the population. Seroepidemiological study may be used both for prognostication purposes and in the system of surveillance on this infection.
首次在甲型病毒性肝炎长期发病周期的三个不同阶段对人群免疫情况进行了研究，并将该研究结果与不同年龄组的发病数据进行了比较。已证实不同年龄组人群免疫结构存在显著差异，且与甲型肝炎发病动态相关。免疫水平波动在1至6岁和7至14岁儿童中最为明显，这些儿童血清阳性者比例最低。在这些人群组中开始了新的流行周期，在第一阶段，该周期表现为潜在发展的流行过程强度增加。随后，整个人群中登记发病率上升。血清流行病学研究可用于预测目的以及该感染的监测系统。
