Sethuraman S, Mahamood M, Kareem S
Department of Paediatrics, Calicut Medical College, India.
Ann Trop Paediatr. 1994;14(4):321-4. doi: 10.1080/02724936.1994.11747736.
Multi-drug-resistant Salmonella typhi infection is an emerging public health problem in most developing countries. Fifty children up to the age of 12 years whose blood cultures were positive for S. typhi, mostly drug-resistant ones, were treated with oral furazolidone in a prospective year-long study. Defervescence occurred in 96% of the treated group with a mean duration for response of 5.9 days. No clinically significant side-effects were noted. Furazolidone was found to be efficacious, safe and cost-effective in the treatment of most cases of childhood typhoid fever caused by multi-resistant S. typhi.
多重耐药性伤寒沙门氏菌感染在大多数发展中国家正成为一个新出现的公共卫生问题。在一项为期一年的前瞻性研究中，对50名12岁以下血培养伤寒沙门氏菌呈阳性（大多数为耐药菌）的儿童给予口服呋喃唑酮治疗。治疗组中96%的患儿退热，平均退热时间为5.9天。未观察到具有临床意义的副作用。结果发现，呋喃唑酮在治疗大多数由多重耐药伤寒沙门氏菌引起的儿童伤寒热病例中有效、安全且具有成本效益。
