Blauvelt A, Turner M L
Dermatology Branch, National Cancer Institute, Bethesda, Md.
Arch Dermatol. 1994 Apr;130(4):481-3.
Patients with Gianotti-Crosti syndrome (GCS) present with a distinctive self-limiting acral papular or papulovesicular eruption associated with an underlying viral illness. Gianotti-Crosti syndrome in patients infected with human immunodeficiency virus has not been previously reported.
We report on two children infected with human immunodeficiency virus who had GCS. Both patients had clinical and histopathologic findings characteristic of GCS. The first patient had evidence of prior infection with cytomegalovirus, without evidence of active viral illness. The second patient had evidence of subclinical infection with cytomegalovirus, positive hepatitis C antibody, and active infection with Mycobacterium avium-intracellulare at the time the skin eruption began.
We call attention to a previously unreported skin eruption, GCS, in the setting of human immunodeficiency virus infection and emphasize that determining the etiologic factors for human immunodeficiency virus-associated GCS will be difficult; such patients will probably have a variety of clinical and subclinical infections that complicate this issue.
Gianotti-Crosti综合征（GCS）患者表现为一种独特的自限性肢端丘疹或丘疹水疱性皮疹，与潜在的病毒感染有关。先前尚未报道过感染人类免疫缺陷病毒（HIV）的患者出现Gianotti-Crosti综合征。
我们报告了两名感染HIV且患有GCS的儿童。两名患者均具有GCS的临床和组织病理学特征。第一名患者有巨细胞病毒既往感染的证据，但无活动性病毒感染的证据。第二名患者在皮疹开始时，有巨细胞病毒亚临床感染的证据、丙型肝炎抗体阳性以及鸟分枝杆菌胞内菌感染。
我们提醒注意在HIV感染情况下先前未报道过的皮疹——GCS，并强调确定HIV相关GCS的病因将很困难；此类患者可能有多种临床和亚临床感染，使这个问题变得复杂。
