Møiniche S, Pedersen J L, Kehlet H
Department of Anaesthesiology and Surgical Gastroenterology, Hvidovre University Hospital, Denmark.
Burns. 1994 Dec;20(6):483-6. doi: 10.1016/0305-4179(94)90001-9.
This study investigated the antinociceptive and anti-inflammatory effect of a topical non-steroidal anti-inflammatory drug in human thermal injury. Twelve healthy unmedicated volunteers had identical burn injuries produced on the medial side of both calves with a 49 degrees C 15 x 25 mm thermode. Ketorolac gel or placebo were randomly applied on the right or left calf 1.5 h before burn injury, immediately after burn injury and 6 and 12 h later in a double-blind trial where every subject served as his own control. Heat pain detection thresholds (HPDT), head pain tolerance (HPT), mechanical pain detection thresholds (MPDT) and the intensity of burn-induced erythema (erythema index, EI) were assessed in the area of the thermal injury, and areas of hyperalgesia to pin prick were determined outside the injury before and 3, 6 and 24 h after the burn injury. Burn injury led to a decrease in HPDT, HPT and MPDT, an increase in EI and development of mechanical hyperalgesia (P < 0.05). Ketorolac gel had no effect on any of the nociceptive or inflammatory variables studies (P > 0.2).
本研究调查了一种外用非甾体抗炎药对人体热损伤的抗伤害感受和抗炎作用。12名未用药的健康志愿者双侧小腿内侧用49摄氏度、15×25毫米的热探头造成相同的烧伤。在一项双盲试验中，酮咯酸凝胶或安慰剂在烧伤前1.5小时、烧伤后立即以及6小时和12小时后随机涂于右小腿或左小腿，每个受试者均作为自身对照。评估热损伤区域的热痛检测阈值（HPDT）、热痛耐受（HPT）、机械痛检测阈值（MPDT）以及烧伤诱导的红斑强度（红斑指数，EI），并在烧伤前以及烧伤后3小时、6小时和24小时测定损伤区域外对针刺的痛觉过敏区域。烧伤导致HPDT、HPT和MPDT降低，EI升高以及机械性痛觉过敏的出现（P<0.05）。酮咯酸凝胶对所研究的任何伤害感受或炎症变量均无影响（P>0.2）。
