Shibata S, Watanabe S
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Brain Res. 1994 Nov 28;665(1):147-50. doi: 10.1016/0006-8993(94)91165-7.
The aim of the present study was to determine whether the 2-deoxyglucose uptake of amygdala slices was affected by olfactory bulbectomy. At 7, 14 and 21 days post-lesion, bilateral olfactory bulbectomized rats exhibited a significant increase of 2-deoxyglucose uptake in amygdala slices, but not in the cerebral cortex. In addition, unilateral olfactory bulbectomized rats showed a high uptake of 2-deoxyglucose uptake in the ipsilateral amygdala, but not in the contralateral amygdala. These results suggest that the enhancement of 2-deoxyglucose uptake is related to the hyperexcitability of amygdala neurons following bulbectomy, and that this enhancement may be responsible for the behavioral changes in olfactory bulbectomized rats.
本研究的目的是确定嗅球切除是否会影响杏仁核切片对2-脱氧葡萄糖的摄取。在损伤后7天、14天和21天，双侧嗅球切除的大鼠杏仁核切片中2-脱氧葡萄糖摄取显著增加，但大脑皮层未出现这种情况。此外，单侧嗅球切除的大鼠同侧杏仁核中2-脱氧葡萄糖摄取较高，而对侧杏仁核未出现这种情况。这些结果表明，2-脱氧葡萄糖摄取的增强与嗅球切除后杏仁核神经元的过度兴奋有关，并且这种增强可能是嗅球切除大鼠行为变化的原因。
