溃疡性结肠炎合并恶性淋巴瘤：病例报告及已发表文献分析

Lenzen R, Borchard F, Lübke H, Strohmeyer G

Department of Medicine, Heinrich-Heine-University, Düsseldorf, Germany.

Gut. 1995 Feb;36(2):306-10. doi: 10.1136/gut.36.2.306.

A 51 year old woman with a two year history of ulcerative colitis developed a wide spread gastrointestinal non-Hodgkin's lymphoma of low grade malignancy (MALT-lymphoma) involving upper and lower gastrointestinal tract, spleen, and bone marrow. After chemotherapy, clinical symptoms improved and lymphocytic infiltrates disappeared. Thirty nine cases of ulcerative colitis and 22 cases of Crohn's disease complicated by gastrointestinal lymphomas reported in published works are reviewed. In inflammatory bowel diseases any dense lymphocytic infiltrates seen in biopsy specimens obtained from ulcerative colitis or Crohn's disease should be assessed to exclude gastrointestinal lymphoma.

一名患有溃疡性结肠炎两年的51岁女性患上了广泛播散的低级别恶性胃肠道非霍奇金淋巴瘤（黏膜相关淋巴组织淋巴瘤），累及上、下胃肠道、脾脏和骨髓。化疗后，临床症状改善，淋巴细胞浸润消失。本文回顾了已发表文献中报道的39例溃疡性结肠炎和22例克罗恩病合并胃肠道淋巴瘤的病例。在炎症性肠病中，对于从溃疡性结肠炎或克罗恩病活检标本中发现的任何密集淋巴细胞浸润，都应进行评估以排除胃肠道淋巴瘤。