Kanazawa A, Ikeda T, Endo T
Research Laboratory of Resources Utilization, Tokyo Institute of Technology, Yokohama, Japan.
J Appl Bacteriol. 1995 Jan;78(1):55-60. doi: 10.1111/j.1365-2672.1995.tb01673.x.
A new concept for the mode of action of cationic biocides is proposed in which the antibacterial activity of cationic disinfectants is ascribed essentially to molecular organizations of cations within aggregates, i.e. the activity is determined by the size of aggregates and number of active molecules comprising the aggregate. On the basis of the new concept, the morphological effect of disinfectants in aqueous solution on the antibacterial activity is discussed for low molecular weight phosphonium salts with single and double long alkyl chains (carbon number 14). The proposed new concept can be applied to all phenomena reported previously in antibacterial activity of cationic biocides and this concept is very important from the viewpoint of molecular design of more active cationic biocides.
提出了一种关于阳离子杀菌剂作用方式的新概念，其中阳离子消毒剂的抗菌活性主要归因于聚集体内阳离子的分子组织，即活性由聚集体的大小和构成聚集体的活性分子数量决定。基于这一新概念，讨论了具有单长烷基链和双长烷基链（碳原子数为14）的低分子量鏻盐在水溶液中消毒剂的形态对其抗菌活性的影响。所提出的新概念可应用于先前报道的阳离子杀菌剂抗菌活性的所有现象，并且从设计更具活性的阳离子杀菌剂的分子角度来看，这一概念非常重要。
