Vidailhet M, Atchison P R, Stocchi F, Thompson P D, Rothwell J C, Marsden C D
Medical Research Council/Human Movement and Balance Unit, London, England.
Mov Disord. 1995 Jan;10(1):18-21. doi: 10.1002/mds.870100105.
The cerebral activity preceding voluntary, self-paced ankle dorsiflexion movements while seated was compared with that before a stepping movement of the same foot while standing in four patients with isolated gait ignition failure. Results within the patients group were variable, but all exhibited some increase in the Bereitschaftspotential (BP) amplitude when stepping as compared with sitting, similar to that seen in normal subjects. This differs from previous results in patients with Parkinson's disease in which stepping was not accompanied by a normal increase in BP amplitude. This difference suggests that the mechanisms responsible for the start hesitation that is common to both Parkinson's disease and gait ignition failure may differ in the two conditions.
在四名患有孤立性步态启动失败的患者中，比较了他们坐着时进行自主、自定步速的踝关节背屈运动之前的大脑活动，以及同一只脚站立时进行迈步运动之前的大脑活动。患者组内的结果各不相同，但与坐着时相比，所有患者在迈步时 Bereitschaftspotential（BP）振幅均有一定增加，这与正常受试者的情况相似。这与帕金森病患者之前的结果不同，帕金森病患者迈步时 BP 振幅没有正常增加。这种差异表明，帕金森病和步态启动失败共有的起始犹豫的机制在这两种情况下可能不同。
