Répérant J M, Naciri M, Iochmann S, Tilley M, Bout D T
Unité de Recherche Université-INRA d'Immunologie Parasitaire, UFR des Sciences Pharmaceutiques, Centre INRA de Tours, Nouzilly, France.
Vet Parasitol. 1994 Oct;55(1-2):1-13. doi: 10.1016/0304-4017(94)90051-5.
Serum humoral immune response to Cryptosporidium parvum was evaluated in six species: mouse, rabbit, lamb, calf, pig and man. Electrophoretic and immunoblot analysis showed that specific animal antibody response appeared between Day 4 and Day 15 post inoculation. The two main target antigens had apparent molecular weights of 15-17 and 23 kDa. They were recognised by each species studied. Serum IgA intensively recognised the 15-17 kDa antigen, except in rabbit. This study demonstrates that these two antigens are consistent targets of humoral immune response and can therefore be of great interest in studies of therapy/prophylaxis.
在小鼠、兔、羔羊、犊牛、猪和人六种物种中评估了针对微小隐孢子虫的血清体液免疫反应。电泳和免疫印迹分析表明，接种后第4天至第15天出现了特异性动物抗体反应。两种主要靶抗原的表观分子量分别为15 - 17 kDa和23 kDa。所研究的每个物种都能识别它们。血清IgA强烈识别15 - 17 kDa抗原，但兔除外。本研究表明，这两种抗原是体液免疫反应的一致靶标，因此在治疗/预防研究中可能具有重要意义。
