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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Stark J E, Ellard G A, Gammon P T, Fox W

Br J Clin Pharmacol. 1975 Aug;2(4):355-8. doi: 10.1111/j.1365-2125.1975.tb02784.x.

Isoniazid was used as a marker to monitor the regularity of drug self-administration in a trial of chemoprophylaxis against natural influenza infection. Two hundred and sixty-two volunteers were treated for five weeks with a synthetic isoquinoline compound (U.K. 2371) or a matching placebo. 2. Five marker tablets containing isoniazid (150 mg) were incorporated into each regimen and their ingestion monitored by testing for acetylisoniazid in the urine. 3. Positive evidence of marker tablet consumption was obtained on 75% of the occasions on which urine samples were requested. The results obtained among the volunteers from each treatment group who returned urine specimens as requested (92%) indicated that they had swallowed at least 81% of their prescribed tablets. 4. The findings of the study suggest that when used in this way isoniazid is a very suitable compound for use on a few occasions for monitoring the self-administration of drugs in clinical trials.

在一项针对自然流感感染的化学预防试验中，异烟肼被用作监测药物自我给药规律的标志物。262名志愿者接受了为期五周的合成异喹啉化合物（英国2371）或匹配安慰剂治疗。2. 每种治疗方案中都加入了五片含异烟肼（150毫克）的标记片，并通过检测尿液中的乙酰异烟肼来监测其摄入情况。3. 在75%的要求采集尿液样本的情况下，获得了服用标记片的阳性证据。从每个治疗组中按要求返回尿液样本的志愿者（92%）中得到的结果表明，他们至少服用了规定片剂的81%。4. 该研究结果表明，以这种方式使用时，异烟肼是一种非常适合在临床试验中偶尔用于监测药物自我给药的化合物。

Stark J E, Ellard G A, Gammon P T, Fox W

Br J Clin Pharmacol. 1975 Aug;2(4):355-8. doi: 10.1111/j.1365-2125.1975.tb02784.x.

Isoniazid was used as a marker to monitor the regularity of drug self-administration in a trial of chemoprophylaxis against natural influenza infection. Two hundred and sixty-two volunteers were treated for five weeks with a synthetic isoquinoline compound (U.K. 2371) or a matching placebo. 2. Five marker tablets containing isoniazid (150 mg) were incorporated into each regimen and their ingestion monitored by testing for acetylisoniazid in the urine. 3. Positive evidence of marker tablet consumption was obtained on 75% of the occasions on which urine samples were requested. The results obtained among the volunteers from each treatment group who returned urine specimens as requested (92%) indicated that they had swallowed at least 81% of their prescribed tablets. 4. The findings of the study suggest that when used in this way isoniazid is a very suitable compound for use on a few occasions for monitoring the self-administration of drugs in clinical trials.

在一项针对自然流感感染的化学预防试验中，异烟肼被用作监测药物自我给药规律的标志物。262名志愿者接受了为期五周的合成异喹啉化合物（英国2371）或匹配安慰剂治疗。2. 每种治疗方案中都加入了五片含异烟肼（150毫克）的标记片，并通过检测尿液中的乙酰异烟肼来监测其摄入情况。3. 在75%的要求采集尿液样本的情况下，获得了服用标记片的阳性证据。从每个治疗组中按要求返回尿液样本的志愿者（92%）中得到的结果表明，他们至少服用了规定片剂的81%。4. 该研究结果表明，以这种方式使用时，异烟肼是一种非常适合在临床试验中偶尔用于监测药物自我给药的化合物。