一种监测异烟肼摄入情况的灵敏尿液检测方法。
A sensitive urine-test method for monitoring the ingestion of isoniazid.
作者信息
Ellard G A
出版信息
J Clin Pathol. 1977 Jan;30(1):84-7. doi: 10.1136/jcp.30.1.84.
Abstract
A method is described for monitoring the ingestion of isoniazid based on detecting its metabolites, isonicotinic acid, and isonicotinylglycine in the urine. The sensitivity of the method is high so that reliably positive results were obtained up to about 24 hours after the ingestion of 100 mg isoniazid. The method should facilitate monitoring the taking of isoniazid by tuberculosis patients and the use of isoniazid as a marker for assessing the regularity with which other drugs prescribed for self-administration are actually ingested.
摘要
本文描述了一种基于检测尿液中异烟肼代谢产物异烟酸和异烟酰甘氨酸来监测异烟肼摄入情况的方法。该方法灵敏度高，摄入100mg异烟肼后约24小时内均可可靠地获得阳性结果。该方法应有助于监测结核病患者服用异烟肼的情况，以及将异烟肼用作评估自行服用的其他处方药实际服用规律的标志物。
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本文引用的文献
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A simple spot test to determine whether a patient is taking isoniazid.
Am Rev Respir Dis. 1962 Feb;85:282-4. doi: 10.1164/arrd.1962.85.2.282.
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A NEW METHOD FOR THE DETERMINATION OF N-ACETYL ISONIAZID IN URINE OF AMBULATORY PATIENTS.一种测定门诊患者尿液中N-乙酰异烟肼的新方法。
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Organisational and administrative considerations in the diagnosis and treatment of pulmonary tuberculosis in the developing countries.发展中国家肺结核诊断与治疗中的组织与行政考量
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The determination of isoniazid and its metabolites acetylisoniazid, monoacetylhydrazine, diacetylhydrazine, isonicotinic acid and isonicotinylglycine in serum and urine.血清和尿液中异烟肼及其代谢产物乙酰异烟肼、单乙酰肼、二乙酰肼、异烟酸和异烟酰甘氨酸的测定。
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Sodium nitroprusside test for the detection of isoniazid and acetylisoniazid in urine.用于检测尿液中异烟肼和乙酰异烟肼的硝普钠试验。
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