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1
A sensitive urine-test method for monitoring the ingestion of isoniazid.一种监测异烟肼摄入情况的灵敏尿液检测方法。
J Clin Pathol. 1977 Jan;30(1):84-7. doi: 10.1136/jcp.30.1.84.
2
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4
A sensitive urine-test for monitoring the ingestion of isoniazid.一种用于监测异烟肼摄入情况的灵敏尿液检测方法。
J Clin Pathol. 1978 Jan;31(1):97-8. doi: 10.1136/jcp.31.1.97.
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The determination of isoniazid and its metabolites acetylisoniazid, monoacetylhydrazine, diacetylhydrazine, isonicotinic acid and isonicotinylglycine in serum and urine.血清和尿液中异烟肼及其代谢产物乙酰异烟肼、单乙酰肼、二乙酰肼、异烟酸和异烟酰甘氨酸的测定。
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6
Fluorometric determination of isoniazid and its metabolites in urine by high-performance liquid chromatography using in-line derivatization.
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Am Rev Respir Dis. 1972 Dec;106(6):923-4. doi: 10.1164/arrd.1972.106.6.923.
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10
N1-sulfato-N2-isonicotinylhydrazine. A potential metabolite of isoniazid.
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Point-of-care urine tests for smoking status and isoniazid treatment monitoring in adult patients.即时检测尿液用于成人患者吸烟状况和异烟肼治疗监测。
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Childhood tuberculosis at a Swiss university hospital: a 2-year study.瑞士一家大学医院的儿童结核病：一项为期两年的研究。
Eur J Pediatr. 1993 Oct;152(10):805-9. doi: 10.1007/BF02073375.
3
An evaluation of the potential use of isoniazid, acetylisoniazid and isonicotinic acid for monitoring the self-administration of drugs.对异烟肼、乙酰异烟肼和异烟酸在监测药物自我给药方面潜在用途的评估。
Br J Clin Pharmacol. 1980 Oct;10(4):369-81. doi: 10.1111/j.1365-2125.1980.tb01773.x.
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Compliance of patients and physicians: experience and lessons from tuberculosis-II.患者与医生的依从性：结核病防治的经验与教训（二）
Br Med J (Clin Res Ed). 1983 Jul 9;287(6385):101-5. doi: 10.1136/bmj.287.6385.101.
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7
A sensitive urine-test for monitoring the ingestion of isoniazid.一种用于监测异烟肼摄入情况的灵敏尿液检测方法。
J Clin Pathol. 1978 Jan;31(1):97-8. doi: 10.1136/jcp.31.1.97.

本文引用的文献

1
A simple spot test to determine whether a patient is taking isoniazid.
Am Rev Respir Dis. 1962 Feb;85:282-4. doi: 10.1164/arrd.1962.85.2.282.
2
A NEW METHOD FOR THE DETERMINATION OF N-ACETYL ISONIAZID IN URINE OF AMBULATORY PATIENTS.一种测定门诊患者尿液中N-乙酰异烟肼的新方法。
Am Rev Respir Dis. 1964 Apr;89:587-8. doi: 10.1164/arrd.1964.89.4.587.
3
A comparison of various methods for the detection of isoniazid and its metabolites in urine.
Tubercle. 1965 Sep;46(3):262-9. doi: 10.1016/s0041-3879(65)80020-4.
4
Organisational and administrative considerations in the diagnosis and treatment of pulmonary tuberculosis in the developing countries.发展中国家肺结核诊断与治疗中的组织与行政考量
Tubercle. 1968 Sep;49(3):332-46. doi: 10.1016/0041-3879(68)90056-1.
5
The determination of isoniazid and its metabolites acetylisoniazid, monoacetylhydrazine, diacetylhydrazine, isonicotinic acid and isonicotinylglycine in serum and urine.血清和尿液中异烟肼及其代谢产物乙酰异烟肼、单乙酰肼、二乙酰肼、异烟酸和异烟酰甘氨酸的测定。
Biochem J. 1972 Feb;126(3):449-58. doi: 10.1042/bj1260449.
6
Sodium nitroprusside test for the detection of isoniazid and acetylisoniazid in urine.用于检测尿液中异烟肼和乙酰异烟肼的硝普钠试验。
Tubercle. 1967 Mar;48(1):45-50. doi: 10.1016/s0041-3879(67)80051-5.
7
General considerations in the choice and management of regimens of chemotherapy for pulmonary tuberculosis.肺结核化疗方案选择与管理的一般考量
Bull Int Union Tuberc. 1972 Feb;47:49-67.
8
The therapy of pulmonary tuberculosis in Kenya: a comparison of the results achieved in controlled clinical trials with those achieved by the routine treatment services.肯尼亚的肺结核治疗：对照临床试验结果与常规治疗服务结果的比较。
Tubercle. 1970 Mar;51(1):24-38. doi: 10.1016/0041-3879(70)90125-x.
9
Pharmacokinetics of isoniazid metabolism in man.
J Pharmacokinet Biopharm. 1976 Apr;4(2):83-113. doi: 10.1007/BF01086149.
10
The use of isoniazid as a marker to monitor the self-administration of medicaments.使用异烟肼作为监测药物自我给药情况的标志物。
Br J Clin Pharmacol. 1975 Aug;2(4):355-8. doi: 10.1111/j.1365-2125.1975.tb02784.x.

一种监测异烟肼摄入情况的灵敏尿液检测方法。

A sensitive urine-test method for monitoring the ingestion of isoniazid.

作者信息

Ellard G A

出版信息

J Clin Pathol. 1977 Jan;30(1):84-7. doi: 10.1136/jcp.30.1.84.

DOI:10.1136/jcp.30.1.84
PMID:838875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476653/
Abstract

A method is described for monitoring the ingestion of isoniazid based on detecting its metabolites, isonicotinic acid, and isonicotinylglycine in the urine. The sensitivity of the method is high so that reliably positive results were obtained up to about 24 hours after the ingestion of 100 mg isoniazid. The method should facilitate monitoring the taking of isoniazid by tuberculosis patients and the use of isoniazid as a marker for assessing the regularity with which other drugs prescribed for self-administration are actually ingested.

摘要

本文描述了一种基于检测尿液中异烟肼代谢产物异烟酸和异烟酰甘氨酸来监测异烟肼摄入情况的方法。该方法灵敏度高，摄入100mg异烟肼后约24小时内均可可靠地获得阳性结果。该方法应有助于监测结核病患者服用异烟肼的情况，以及将异烟肼用作评估自行服用的其他处方药实际服用规律的标志物。