de Vries J E, Zurawski G
Human Immunology and Molecular Biology Department, DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, Calif 94304-1104.
Int Arch Allergy Immunol. 1995 Mar;106(3):175-9. doi: 10.1159/000236842.
IL-13 is a relatively novel cytokine produced by activated T cells. IL-13 inhibits the production of proinflammatory cytokines and chemokines by activated monocytes, induces B cell proliferation and differentiation, including IgE production, and the expression of certain adhesion molecules on endothelial cells. All these biological properties of IL-13 are shared with IL-4, but in contrast to IL-4, IL-13 does not act on T cells. In this review, the similarities in structure and biological function of IL-13 and IL-4 and the commonalities of their receptors are summarized. The potential role of IL-13 in allergic responses is briefly discussed.
白细胞介素-13（IL-13）是一种由活化T细胞产生的相对较新的细胞因子。IL-13可抑制活化单核细胞产生促炎细胞因子和趋化因子，诱导B细胞增殖和分化，包括IgE的产生，以及内皮细胞上某些黏附分子的表达。IL-13的所有这些生物学特性与IL-4相同，但与IL-4不同的是，IL-13不作用于T细胞。在这篇综述中，总结了IL-13和IL-4在结构和生物学功能上的相似性以及它们受体的共性。简要讨论了IL-13在过敏反应中的潜在作用。
