Nelson M, Forsyth C, Popp H, Gibson J
Haematology Department, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Transfus Med. 1994 Dec;4(4):297-302. doi: 10.1111/j.1365-3148.1994.tb00267.x.
Rh(D)- and K-negative women who have become severely isoimmunized by pregnancy are at risk of fetal loss or damage in subsequent pregnancies. A flow cytometric method is described whereby the presence of Rh(D) or K antigen on fetal erythrocytes may be determined using chorion villus samples taken during the first trimester. This method has the advantage of speed and sensitivity with results being available within 2 h. Decisions as to management of the pregnancy or termination may thus be made with minimal delay.
因妊娠而发生严重同种免疫的 Rh(D)阴性和 K 阴性女性，在后续妊娠中有胎儿丢失或受损的风险。本文描述了一种流式细胞术方法，通过该方法可以使用孕早期采集的绒毛膜绒毛样本确定胎儿红细胞上 Rh(D)或 K 抗原的存在。该方法具有速度快和灵敏度高的优点，2 小时内即可获得结果。因此，可以在最短的延迟时间内做出关于妊娠管理或终止妊娠的决定。
