Pedersen C A, Caldwell J D, Walker C, Ayers G, Mason G A
Department of Psychiatry, University of North Carolina at Chapel Hill 27599-7250.
Behav Neurosci. 1994 Dec;108(6):1163-71. doi: 10.1037//0735-7044.108.6.1163.
Oxytocin binding (Bmax) was found to be higher in the ventral tegmental area (VTA) and the medial preoptic area (MPOA) at midparturition compared with Pregnancy Days 15-17 or Postpartum Days 5-7 in rat dams. Pup retrieval and assuming a nursing posture over pups were blocked in parturient dams by infusions of an oxytocin antagonist into the VTA or MPOA and by infusions of a vasopressin (V1) antagonist into the MPOA. These results implicate oxytocin in the VTA and MPOA and vasopressin in the MPOA, as well as a parturition-associated rise in oxytocin binding in these sites in the postpartum activation of maternal behavior.
与妊娠第15 - 17天或产后第5 - 7天的大鼠母鼠相比，发现分娩中期腹侧被盖区（VTA）和内侧视前区（MPOA）的催产素结合（Bmax）更高。向VTA或MPOA注入催产素拮抗剂，以及向MPOA注入血管加压素（V1）拮抗剂，可部分阻断分娩母鼠的幼崽找回行为和对幼崽采取哺乳姿势的行为。这些结果表明，VTA和MPOA中的催产素以及MPOA中的血管加压素，以及这些部位催产素结合在产后母体行为激活中与分娩相关的升高。
