Vidal J, Rama R
Department of Personality, School of Psychology, University of Barcelona, Spain.
Behav Neurosci. 1994 Dec;108(6):1172-8. doi: 10.1037//0735-7044.108.6.1172.
Researchers attempted to find a genetic correlation between the antibody response and some behaviors by comparing the behavioral profile of good antibody-producing mice (Biozzi's H mice) with that of bad antibody producers (Biozzi's L mice). The behavioral tests used were 2 open fields, a light-darkness test, and reaction to capture; the antigen was keyhole limpet hemocyanin, and blood levels of immunoglobulin (Classes IgM and IgG) antibodies to hemocyanin were measured by diffusion-in-gel-enzyme-linked immunosorbent assay. H and L mice differed in the magnitude of the antibody response (H > L), in reaction to capture (L > H), and in rearing in 1 of the open fields (L > H). Yet the level of IgM or IgG antibodies was uncorrelated with those behaviors in the (H x L) F2 hybrids and in outbred CD1 mice. Thus, the behavioral differences between H and L mice are not due to the antibody response genes but to other genes fixed during selection for antibody responsiveness.
研究人员试图通过比较抗体产生良好的小鼠（比奥齐的H小鼠）和抗体产生不良的小鼠（比奥齐的L小鼠）的行为特征，来寻找抗体反应与某些行为之间的遗传相关性。所使用的行为测试包括2个旷场试验、明暗试验和捕捉反应试验；抗原为钥孔戚血蓝蛋白，通过凝胶扩散酶联免疫吸附测定法测量血蓝蛋白免疫球蛋白（IgM和IgG类）抗体的水平。H小鼠和L小鼠在抗体反应强度（H>L）、捕捉反应（L>H）以及在其中一个旷场中的饲养情况（L>H）方面存在差异。然而，在（H×L）F2杂交种和远交系CD1小鼠中，IgM或IgG抗体水平与这些行为并无相关性。因此，H小鼠和L小鼠之间的行为差异并非由于抗体反应基因，而是由于在选择抗体反应性过程中固定下来的其他基因。
