Fuller M, Dobson J, Wieser H G, Moser S
Dept. of Geological Sciences, University of California at Santa Barbara 93106.
Brain Res Bull. 1995;36(2):155-9. doi: 10.1016/0361-9230(94)00183-2.
Evocation of epileptiform activity by DC magnetic fields of between 0.9 and 1.8 millitesla (mT) has been demonstrated in 6 epileptic patients undergoing presurgical evaluation. The activity was monitored by electroencephalography (EEG) recording from both electrodes attached to the scalp as well as from intracranial electrodes inserted via the foramen ovale. Epileptiform activity evoked by the magnetic field application was distinguished from background levels by comparing the number of epileptiform discharges in the 10-s intervals before and after field applications. In nearly all cases, a delay of up to several seconds was observed between the application of the magnetic field and the onset of epileptiform firing. Removal of the field also appeared to cause firing in some instances, but this has not yet been investigated systematically. In all 6 patients, subsequent seizures confirmed that the epileptiform activity monitored during the experiments was originating from the primary epileptogenic zones of the patients.
在6名接受术前评估的癫痫患者中，已证实0.9至1.8毫特斯拉（mT）的直流磁场可诱发癫痫样活动。通过连接到头皮的电极以及经卵圆孔插入的颅内电极进行脑电图（EEG）记录来监测该活动。通过比较磁场施加前后10秒间隔内癫痫样放电的数量，将磁场施加诱发的癫痫样活动与背景水平区分开来。在几乎所有情况下，在施加磁场和癫痫样放电开始之间观察到长达数秒的延迟。在某些情况下，去除磁场似乎也会引发放电，但尚未对此进行系统研究。在所有6名患者中，随后的癫痫发作证实了实验期间监测到的癫痫样活动源自患者的原发性癫痫灶。
