Nordsletten L, Kaastad T S, Madsen J E, Reikerås O, Ovstebø R, Strømme J H, Falch J
Institute for Surgical Research, Rikshospitalet, Oslo, Norway.
Calcif Tissue Int. 1994 Dec;55(6):436-42. doi: 10.1007/BF00298557.
The effect of treadmill running on the development of osteopenia was investigated in adult ovariectomized (OVX) rats compared with sedentary OVX and sedentary sham-operated rats. The rats were 3 months old with a mean weight of 214 g. OVX rats were fed a low calcium diet (0.01%), and the sham rats received the normal diet (1.1% calcium). The training consisted of treadmill running at a speed of 27 m/minute for 1 hour 5 out of 7 days during a period of 8 1/2 weeks. The weight gain was higher in the sedentary OVX (108 g) than in the training OVX (62 g) and sham-operated rats (61 g) (P < 0.001). Comparing the two OVX groups, training had no significant effects on the development of femoral osteopenia as assessed by mechanical testing of the femoral shaft and neck, and by bone mass measurements by dual energy X-ray absorptiometry (DXA) or by ashing. Comparing all three groups bone mineral content (BMC) and bone mineral density (BMD) were reduced by more than 40% in both the OVX groups compared with the sham-operated rats (P < 0.001). Ash weight and calcium content were reduced by approximately 40% in both OVX groups. Femoral volume and length were 10% higher in the sedentary OVX animals compared with the trained (P < 0.05), indicating that the training had had a negative effect on the growth changes induced by ovariectomy. The fracture strength of the femoral shaft was reduced by 26% and 22% in the trained and sedentary OVX rats, respectively compared with the sham-operated group (P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
研究了成年去卵巢（OVX）大鼠跑步机跑步对骨质减少发展的影响，并与久坐的OVX大鼠和久坐的假手术大鼠进行比较。这些大鼠3个月大，平均体重214克。OVX大鼠喂食低钙饮食（0.01%），假手术大鼠喂食正常饮食（1.1%钙）。训练包括在8.5周的时间里，每周5天以27米/分钟的速度在跑步机上跑1小时。久坐的OVX大鼠体重增加（108克）高于训练的OVX大鼠（62克）和假手术大鼠（61克）（P<0.001）。比较两个OVX组，通过股骨干和颈部力学测试、双能X线吸收法（DXA）或灰化法测量骨量，训练对股骨骨质减少的发展没有显著影响。比较所有三组，与假手术大鼠相比，两个OVX组的骨矿物质含量（BMC）和骨矿物质密度（BMD）均降低了40%以上（P<0.001）。两个OVX组的灰重和钙含量均降低了约40%。与训练组相比，久坐的OVX动物的股骨体积和长度高10%（P<0.05），表明训练对去卵巢诱导的生长变化有负面影响。与假手术组相比，训练的和久坐的OVX大鼠股骨干的骨折强度分别降低了26%和22%（P<0.001）。（摘要截断于250字）
