Arendt G, Hefter H, Neuen-Jacob E, Wist S, Kuhlmann H, Strohmeyer G, Freund H J
Department of Neurology, University of Düsseldorf, Germany.
J Neurol. 1993 Jul;240(7):439-45. doi: 10.1007/BF00867359.
Thirty-three HIV-positive patients with clinical signs of dementia according to the 1991 AAN criteria underwent psychometric, electrophysiological and radiological examination and were compared with a group of normal healthy subjects and a cohort of clinically asymptomatic HIV-1-positive individuals of comparable education and social environment. Compared with the other groups, test performance was severely impaired in the demented patients. Results of motor testing and MRI revealed that subcortical structures were not exclusively affected, but most severely and early, thus characterizing the clinical feature in HIV-1-associated dementia. In demented patients a rapid deterioration was observed, leading to death within about 12 months on average, which is a markedly shorter survival time than described in the literature for non-demented HIV-1-positive individuals.
根据1991年美国神经病学学会（AAN）标准，33例有痴呆临床症状的HIV阳性患者接受了心理测量、电生理和放射学检查，并与一组正常健康受试者以及一群教育程度和社会环境相当的临床无症状HIV-1阳性个体进行了比较。与其他组相比，痴呆患者的测试表现严重受损。运动测试和MRI结果显示，皮质下结构并非仅受影响，而是受影响最严重且最早，从而确定了HIV-1相关痴呆的临床特征。在痴呆患者中观察到病情迅速恶化，平均约12个月内死亡，这一存活时间明显短于文献中描述的非痴呆HIV-1阳性个体。
