Sarkisian S V
Klin Med (Mosk). 1994;72(6):45-8.
105 patients with chronic diffuse diseases of the liver were examined clinically, biochemically and immunologically. The examination included investigation of serum thymic activity, subpopulation of peripheral blood lymphocytes using monoclonal antibodies, immunoglobulins (A, M, G) and CIC. Thymic activity in the serum was low in chronic persistent hepatitis, much lower in chronic active hepatitis and the lowest in hepatic cirrhosis. Thymic activity correlated with the process activity and compensation, peripheral blood levels of T-lymphocytes, T-helpers, T-suppressors. The conclusion is made on thymic deficiency in chronic diffuse hepatic diseases. Correction of chronic secondary thymic insufficiency with T-activin produced a good clinical response.
对105例慢性弥漫性肝病患者进行了临床、生化和免疫检查。检查项目包括血清胸腺活性、使用单克隆抗体检测外周血淋巴细胞亚群、免疫球蛋白（A、M、G）和循环免疫复合物（CIC）。慢性持续性肝炎患者血清中的胸腺活性较低，慢性活动性肝炎患者的胸腺活性更低，而肝硬化患者的胸腺活性最低。胸腺活性与病情活动度和代偿情况、外周血T淋巴细胞、辅助性T细胞、抑制性T细胞水平相关。得出慢性弥漫性肝病存在胸腺缺陷的结论。用T激活素纠正慢性继发性胸腺功能不全产生了良好的临床反应。
