Wilkins D E, Raaphorst G P, Saunders J K, Sutherland G R, Smith I C
Ottawa Regional Cancer Centre, Ontario, Canada.
Magn Reson Imaging. 1995;13(1):89-96. doi: 10.1016/0730-725x(94)00072-b.
Gadolinium-based MR imaging contrast agents cause signal enhancement of intracerebral tumors on T1-weighted MR images because they cross the compromised blood-brain barrier, increasing the T1 relaxation rate of extracellular water. Tumor extent measured by Gd-enhanced MR imaging often does not agree with T2-weighted MRI or biopsy measurements, due to possible peritumoral barrier defects or infiltration of tumor cells beyond the region of enhancement. In this study, the 9L rat brain tumor model was used to measure the correlation between tumor size measured by Gd-enhanced and unenhanced MRI and histological measurements. There was excellent agreement between Gd-enhanced MRI measurements and histology. Morphological features of untreated 9L intracranial tumors and those treated with radiation and/or cisplatin were compared with histological features. No significant change in intracranial tumor size was detected in the treated animals up to 7 days following treatment, despite substantial tumor necrosis evident on histological analysis.
基于钆的磁共振成像造影剂会使脑肿瘤在T1加权磁共振图像上信号增强，因为它们能够穿过受损的血脑屏障，提高细胞外水的T1弛豫率。通过钆增强磁共振成像测量的肿瘤范围往往与T2加权磁共振成像或活检测量结果不一致，这是由于可能存在肿瘤周围屏障缺陷或肿瘤细胞浸润超出增强区域。在本研究中，使用9L大鼠脑肿瘤模型来测量钆增强和未增强磁共振成像测量的肿瘤大小与组织学测量之间的相关性。钆增强磁共振成像测量结果与组织学结果高度一致。将未经治疗的9L颅内肿瘤以及接受放疗和/或顺铂治疗的肿瘤的形态学特征与组织学特征进行了比较。尽管组织学分析显示肿瘤有大量坏死，但在治疗后的7天内，未检测到治疗动物的颅内肿瘤大小有显著变化。
