Amid P K, Shulman A G, Lichtenstein I L, Sostrin S, Young J, Hakakha M
Department of Surgery Harbor-UCLA.
J Biomed Mater Res. 1994 Mar;28(3):373-5. doi: 10.1002/jbm.820280312.
This preliminary study examined the possibility of preventing intestinal adhesions to biomaterials while preserving their incorporation with the abdominal wall. White New Zealand rabbits received intraperitoneal implants of different biomaterials for repair of defects created on the abdominal wall. The following biomaterials were used: polypropylene, polyester, expanded polytetraflueroethylene, polypropylene mesh/polypropylene sheeting (polypropylene mesh covered with polypropylene sheeting on the peritoneal side), polypropylene/silastic, polypropylene/polyglactin, polypropylene/polyglycolic acid, and polypropylene/fibrin. All biomaterials evaluated caused adhesions to the intestines except for polypropylene mesh/polypropylene sheeting and polypropylene mesh/silastic composites. Because adhesion of the intestine to the biomaterial is the first stage of biomaterial-related intestinal fistula, its prevention is logical for the elimination of this complication. Composites with the selective property of adhering to the abdominal wall, yet sparing the viscera, would facilitate thoracic and abdominal wall surgeries, as well as intraperitoneal laparoscopic hernioplasties.
这项初步研究探讨了在保持生物材料与腹壁融合的同时预防肠管与生物材料粘连的可能性。白色新西兰兔接受了不同生物材料的腹腔内植入，以修复腹壁上制造的缺损。使用了以下生物材料：聚丙烯、聚酯、膨体聚四氟乙烯、聚丙烯网/聚丙烯片（腹膜侧覆盖有聚丙烯片的聚丙烯网）、聚丙烯/硅橡胶、聚丙烯/聚乳酸、聚丙烯/聚乙醇酸以及聚丙烯/纤维蛋白。除聚丙烯网/聚丙烯片和聚丙烯网/硅橡胶复合材料外，所有评估的生物材料均导致肠管粘连。由于肠管与生物材料的粘连是生物材料相关肠瘘的第一阶段，因此预防这种粘连对于消除该并发症具有合理性。具有选择性附着于腹壁而不影响内脏特性的复合材料，将有助于胸腹壁手术以及腹腔内腹腔镜疝修补术。
