Guigui P, Plais P Y, Flautre B, Viguier E, Blary M C, Chopin D, Lavaste F, Hardouin P
Institut de recherche sur les Maladies du Squelette, Berck sur Mer, France.
Spine (Phila Pa 1976). 1994 Dec 15;19(24):2798-803.
The authors evaluated two bone substitutes in a posterolateral spinal arthrodesis (PSA) model in sheep: coral porites (99% calcium carbonate, Biocoral, Inoteb, France) and a biphasic ceramic (BCP) (65% hydroxyapatite and 35% B tricalcium phosphate, Triosite, Zimmer International).
Bone substitutes would be of great interest for PSA. Previous trials began with two kinds of biomaterials: natural coralline calcium carbonate, and phosphate calcium ceramic.
A lumbar PSA was performed in 11 sheep (coral group) and in 9 sheep (BCP group). Sacrifice and biomechanical tests were performed after 1 year.
A large decrease of flexibility in all directions was obtained with both coral PSA and BCP PSA similarly to autologous graft. No nonfusion case was observed.
In conditions close to the human surgery, a PSA can be obtained using either coral porites or BCP as bone substitutes.
作者在绵羊的后外侧脊柱融合术（PSA）模型中评估了两种骨替代物：多孔珊瑚（99%碳酸钙，生物珊瑚，Inoteb，法国）和双相陶瓷（BCP）（65%羟基磷灰石和35%β-磷酸三钙，Triosite，齐默国际公司）。
骨替代物对PSA具有重要意义。先前的试验始于两种生物材料：天然珊瑚碳酸钙和磷酸钙陶瓷。
对11只绵羊（珊瑚组）和9只绵羊（BCP组）进行腰椎PSA。1年后进行处死和生物力学测试。
与自体移植相似，珊瑚PSA和BCP PSA在各个方向上的柔韧性均大幅下降。未观察到不融合病例。
在接近人类手术的条件下，使用多孔珊瑚或BCP作为骨替代物均可实现PSA。
