Mojzis J, Nistiar F, Kovac G
Department of Pharmacology, Medical Faculty of Safarik University, Kosice, Slovak Republic.
Vet Hum Toxicol. 1994 Dec;36(6):533-5.
The inhibitory effect of VX, an organophosphate nerve agent, on tissue and erythrocyte cholinesterase (ChE) and the protective effect of clinoptilolite (Cli) in male Wistar rats were studied. The tissue and erythrocyte ChE activity were significantly inhibited 30 min after 65.5 micrograms VX/kg body weight administration. The greatest enzyme inhibition was observed in erythrocytes, stomach, brain and liver. The ChE activity after pretreatment with 1.0 g Cli/kg was significantly higher than that in the VX without Cli group in all samples except duodenum and colon.
研究了有机磷神经毒剂VX对雄性Wistar大鼠组织和红细胞胆碱酯酶（ChE）的抑制作用以及斜发沸石（Cli）的保护作用。给予65.5微克VX/千克体重后30分钟，组织和红细胞ChE活性受到显著抑制。在红细胞、胃、脑和肝脏中观察到最大程度的酶抑制。除十二指肠和结肠外，在所有样本中，用1.0克Cli/千克预处理后的ChE活性显著高于未用Cli的VX组。
