Mojzis J, Nistiar F, Kovác G, Mojzisová G
Lekárska fakulta Univerzity P. J. Safárika, Kosice.
Vet Med (Praha). 1994;39(8):443-9.
In the present paper the effect of zeolite tuff (61% clinoptilolite) was investigated on cholinesterase activity in brain, liver, spleen, femoral muscle, heart, stomach, duodenum, colon and erythrocytes in sewer-rats after peroral intoxication with VX substance (65.5 micrograms/kg). Fig. 1 shows the ChE activity in the tissues and erythrocytes in the animals of control group and in the group of animals after intoxication with VX substance. The highest activity in the control group was found in brain and duodenum. The enzyme activity in the femoral muscle had the lowest values. A significant decrease in the ChE activity (P < 0.001 or P < 0.01) occurred in all the investigated samples in the group of animals intoxicated with the VX substance. highest enzyme inhibition was observed in erythrocytes (97.9%), stomach (97.9%), brain (95.4%) and liver (94.7%) if compared with the control group. The relatively lowest inhibition was found out in duodenum and colon. In the group administered zeolite before intoxication (1.0 g/kg five minutes before intoxication) the ChE activity was significantly higher in almost all investigated samples than in the group without zeolite (P < 0.001 or P < 0.01)-Fig. 2. The duodenum is an exception, in which the ChE activity in the zeolite group was lower than in the zeolite-free group (P < 0.001), as well as the colon, in which there were no significant differences in the activity between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
在本论文中，研究了凝灰岩沸石（61%斜发沸石）对经口摄入VX物质（65.5微克/千克）的下水道大鼠脑、肝、脾、股肌、心脏、胃、十二指肠、结肠和红细胞中胆碱酯酶活性的影响。图1显示了对照组动物以及VX物质中毒组动物组织和红细胞中的胆碱酯酶活性。对照组中脑和十二指肠的活性最高。股肌中的酶活性值最低。VX物质中毒组所有研究样本中的胆碱酯酶活性均显著降低（P<0.001或P<0.01）。与对照组相比，红细胞（97.9%）、胃（97.9%）、脑（95.4%）和肝（94.7%）中的酶抑制作用最高。十二指肠和结肠中的抑制作用相对最低。在中毒前给予沸石的组（中毒前五分钟给予1.0克/千克）中，几乎所有研究样本中的胆碱酯酶活性均显著高于未给予沸石的组（P<0.001或P<0.01）——图2。十二指肠是个例外，其中沸石组的胆碱酯酶活性低于无沸石组（P<0.001），结肠也是如此，两组之间的活性没有显著差异。（摘要截断于250字）
