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冠状动脉旁路移植术后心律失常与传导障碍:流行病学、管理及预后

Arrhythmias and conduction disturbances after coronary artery bypass graft surgery: epidemiology, management, and prognosis.

作者信息

Pires L A, Wagshal A B, Lancey R, Huang S K

机构信息

Department of Medicine, University of Massachusetts Medical Center, Worcester 01655.

出版信息

Am Heart J. 1995 Apr;129(4):799-808. doi: 10.1016/0002-8703(95)90332-1.

Abstract

CABG is associated with many perioperative complications, including supraventricular and ventricular arrhythmias and conduction disturbances. Atrial fibrillation occurs in < or = 40% of patients after CABG and is especially common in older patients. Although it is often benign and self-limited, it can lead to complications such as stroke. Treatment consists primarily of control of the ventricular response rate; in some cases, antiarrhythmic drugs or electrical cardioversion are needed. Anticoagulation should be considered in appropriate cases of persistent (48 to 72 hours) atrial fibrillation after initial treatment. Prophylaxis, especially with beta-blocking agents, seems to be effective and should be considered in appropriate cases. Simple ventricular arrhythmias are common after CABG and do not affect the patient's prognosis; however, sustained VT/VF occur infrequently (< 2% of patients) and carry a high mortality rate. Treatment is aimed at correcting precipitating factors (e.g., myocardial ischemia). Electrophysiologically guided drug therapy and implantation of an ICD should be considered in appropriate cases for patients who survive the initial events. Transient minor conduction disturbances are common after CABG; in some patients persistent AV block and sinus node dysfunction develop and may require treatment with permanent pacemaker.

摘要

冠状动脉旁路移植术(CABG)与许多围手术期并发症相关,包括室上性和室性心律失常以及传导障碍。冠状动脉旁路移植术后,房颤发生在≤40%的患者中,在老年患者中尤为常见。尽管它通常是良性且自限性的,但可能导致中风等并发症。治疗主要包括控制心室反应率;在某些情况下,需要使用抗心律失常药物或电复律。对于初始治疗后持续(48至72小时)房颤的合适病例,应考虑抗凝治疗。预防措施,尤其是使用β受体阻滞剂,似乎是有效的,在合适病例中应予以考虑。单纯性室性心律失常在冠状动脉旁路移植术后很常见,不影响患者预后;然而,持续性室性心动过速/心室颤动很少发生(<2%的患者),且死亡率很高。治疗旨在纠正诱发因素(如心肌缺血)。对于在初始事件中存活的患者,在合适病例中应考虑电生理指导下的药物治疗和植入植入式心脏除颤器(ICD)。冠状动脉旁路移植术后短暂性轻度传导障碍很常见;在一些患者中,会出现持续性房室传导阻滞和窦房结功能障碍,可能需要永久起搏器治疗。

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