Fung W P, Karim S M
Med J Aust. 1976 Jul 24;2(4):127-8. doi: 10.5694/j.1326-5377.1976.tb130072.x.
A double-blind trial was carried out to assess the effect of 15 (R) 15 methyl prostaglandin E2 on the healing of gastric ulcers. The prostaglandin preparation was given orally in doses of 150 mug every 6 hours for two weeks to 10 subjects with proven gastric ulcer. The control group consisted of 10 subjects with proven gastric ulcer, who did not receive prostaglandin treatment. All were in hospital, and at rest in bed. Ulcer healing was assessed endoscopically with a duodenofibrescope. The maximum diameter of the ulcer crater was determined endoscopically just before and after two weeks of treatment. In the prostaglandin group, complete healing was seen in three cases and considerable healing (50% and more) in five cases, and the overall mean healing rate was 63-3%. In the control group, complete healing was seen in no case and considerable healing in one case, and the overall mean healing rate was 17-1%. The difference was highly significant. The results confirm the belief that 15 (R) 15 methyl prostaglandin E2 is effective in promoting the healing of gastric ulcers.20
进行了一项双盲试验，以评估15（R）15甲基前列腺素E2对胃溃疡愈合的影响。将前列腺素制剂以每6小时150微克的剂量口服给药两周，给予10名经证实患有胃溃疡的受试者。对照组由10名经证实患有胃溃疡的受试者组成，他们未接受前列腺素治疗。所有受试者均住院并卧床休息。用十二指肠纤维镜通过内镜评估溃疡愈合情况。在治疗两周前后，通过内镜确定溃疡 crater 的最大直径。在前列腺素组中，3例完全愈合，5例有显著愈合（50%及以上），总体平均愈合率为63.3%。在对照组中，无病例完全愈合，1例有显著愈合，总体平均愈合率为17.1%。差异非常显著。结果证实了15（R）15甲基前列腺素E2在促进胃溃疡愈合方面有效的观点。
