前列腺素E2对胃溃疡愈合的影响：一项双盲内镜试验

Effect of prostaglandin E2 on the healing of gastric ulcers: a double-blind endoscopic trail.

作者信息

Fung W P, Karim S M

出版信息

Aust N Z J Med. 1976 Apr;6(2):121-2. doi: 10.1111/j.1445-5994.1976.tb03303.x.

DOI:10.1111/j.1445-5994.1976.tb03303.x

Abstract

A double-blind trial was performed to assess the effect of prostaglandin E2 on the healing of gastric ulcers. The prostaglandin preparation was given orally in doses of 1 mg, 6 hourly for two weeks to ten subjects with proven gastric ulcer. The control group consisted of ten subjects with proven gastric ulcer, without prostaglandin treatment. Gastric ulcer healing was assessed endoscopically with a duodenofiberscope. The maximum diameter of the ulcer crater was determined endoscopically just before and after two weeks of treatment. In the prostaglandin group, complete healing was seen in two cases, considerable healing (50% and more) in three cases, and the overall mean healing rate was 42%. In the control group, complete healing was seen in none, considerable healing in one case, and the overall mean healing rate was 14-3%. The difference, statistically, was significant. The results show that prostaglandin E2 is effective in promoting the healing of gastric ulcers.

摘要

进行了一项双盲试验，以评估前列腺素E2对胃溃疡愈合的影响。将前列腺素制剂以1毫克的剂量口服，每6小时一次，给10名已确诊为胃溃疡的受试者服用，持续两周。对照组由10名已确诊为胃溃疡但未接受前列腺素治疗的受试者组成。使用十二指肠纤维镜通过内镜评估胃溃疡的愈合情况。在治疗前和治疗两周后，通过内镜确定溃疡 crater 的最大直径。在前列腺素组中，2例完全愈合，3例有显著愈合（50%及以上），总体平均愈合率为42%。在对照组中，无一例完全愈合，1例有显著愈合，总体平均愈合率为14 - 3%。统计学上，差异具有显著性。结果表明，前列腺素E2在促进胃溃疡愈合方面是有效的。