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紫外线照射后大肠杆菌中诱变DNA修复活性的诱导动力学

Induction kinetics of mutagenic DNA repair activity in E. coli following ultraviolet irradiation.

作者信息

Defais M, Caillet-Fauquet P, Fox M S, Radman M

出版信息

Mol Gen Genet. 1976 Oct 18;148(2):125-30. doi: 10.1007/BF00268375.

DOI:10.1007/BF00268375
PMID:790151
Abstract

Ultraviolet mutagenesis of phage gamma is produced by host functions which are inducible by ultraviolet irradiation of the host cell. Induction kinetics and the half life of the inducible mutagenic DNA repair (SOS-repair) in E.coli have been determined using phage gamma assays. At 37 degrees C, both mutagenic and repair activities are maximal approximately 30 min following irradiation and decay with a half life of approximately 30 min. The presence of 100 mug/ml chloramphenicol during the first 40 min after irradiation completely abolishes induction of repair and mutagenesis. The ultraviolet induction pattern of SOS repair very much resembles that of gamma prophage in lysogenic induction (Monk and Kinross, 1975).

摘要

噬菌体γ的紫外线诱变是由宿主功能产生的，这些宿主功能可通过宿主细胞的紫外线照射诱导产生。利用噬菌体γ试验测定了大肠杆菌中诱导型诱变DNA修复（SOS修复）的诱导动力学和半衰期。在37摄氏度时，诱变和修复活性在照射后约30分钟达到最大值，并以约30分钟的半衰期衰减。照射后最初40分钟内存在100微克/毫升氯霉素会完全消除修复和诱变的诱导。SOS修复的紫外线诱导模式与溶源诱导中γ原噬菌体的诱导模式非常相似（蒙克和金罗斯，1975年）。

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Induction kinetics of mutagenic DNA repair activity in E. coli following ultraviolet irradiation.紫外线照射后大肠杆菌中诱变DNA修复活性的诱导动力学
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Thermal enhancement of ultraviolet mutability in a dnaB uvrA derivative of Escherichia coli B/r: evidence for inducible error-prone repair.大肠杆菌B/r的dnaB uvrA衍生物中紫外线诱变的热增强作用：诱导性易错修复的证据
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Persistence and decay of thermoinducible error-prone repair activity in nonfilamentous derivatives of tif-1, Escherichia coli B/r: the timing of some critical events in ultraviolet mutagenesis.大肠杆菌B/r的tif-1非丝状衍生物中热诱导易错修复活性的持久性和衰减：紫外线诱变中一些关键事件的时间安排
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引用本文的文献

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UV light-induced survival response in a highly radiation-resistant isolate of the Moraxella-Acinetobacter group.莫拉克斯氏菌-不动杆菌属菌群的一种高度耐辐射菌株中的紫外线诱导存活反应。
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本文引用的文献

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Studies on radiation-sensitive mutants of E. coli. 3. Participation of the rec system in induction of mutation by ultraviolet irradiation.大肠杆菌辐射敏感突变体的研究。3. rec 系统在紫外线诱导突变中的作用。
Mol Gen Genet. 1968;103(1):1-10. doi: 10.1007/BF00271151.
5
Mutagenesis by ultraviolet radiation in bacteriophage phiX174: on the mutation stimulating processes induced by ultraviolet radiation in the host bacterium.噬菌体φX174中紫外线诱导的诱变作用：关于宿主细菌中紫外线诱导的突变刺激过程
Mol Gen Genet. 1974;135(1):19-27. doi: 10.1007/BF00433897.
6
Thermal enhancement of ultraviolet mutability in a tif-1 uvrA derivative of Escherichia coli B-r: evidence that ultraviolet mutagenesis depends upon an inducible function.大肠杆菌B-r的tif-1 uvrA衍生物中紫外线诱变的热增强：紫外线诱变依赖于一种可诱导功能的证据。
Proc Natl Acad Sci U S A. 1974 May;71(5):1930-4. doi: 10.1073/pnas.71.5.1930.
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Indirect ultraviolet-reactivation of phage lambda.噬菌体λ的间接紫外线复活作用。
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Isolation of conditional defective mutants of temperate phage Mu-1 and deletion mapping of the Mu-1 prophage.温和噬菌体Mu-1条件性缺陷突变体的分离及Mu-1原噬菌体的缺失定位
Virology. 1973 Jul;54(1):117-24. doi: 10.1016/0042-6822(73)90121-9.
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Prophage induction and cell division in E. coli. I. Further characterization of the thermosensitive mutation tif-1 whose expression mimics the effect of UV irradiation.大肠杆菌中的原噬菌体诱导与细胞分裂。I. 温度敏感突变体tif-1的进一步特征分析，其表达模拟紫外线照射的效应。
Mol Gen Genet. 1972;119(2):139-52. doi: 10.1007/BF00269133.
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Prophage induction and cell division in E. coli. III. Mutations sfiA and sfiB restore division in tif and lon strains and permit the expression of mutator properties of tif.大肠杆菌中的原噬菌体诱导与细胞分裂。III. 突变体sfiA和sfiB恢复了tif和lon菌株中的细胞分裂，并使tif的诱变特性得以表达。
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