Murase S, Grenhoff J, Chouvet G, Gonon F G, Svensson T H
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Neurosci Lett. 1993 Jul 9;157(1):53-6. doi: 10.1016/0304-3940(93)90641-w.
The influence of the medial prefrontal cortex (PFC) on mesolimbic dopamine activity was studied with electrophysiological techniques and in vivo voltammetry in the chloral hydrate-anesthetized male rat. Glutamate injected into the PFC selectively increased burst firing of single dopamine cells in the ventral tegmental area and enhanced the release of dopamine from nerve terminals in the nucleus accumbens. PFC injection of the local anesthetic lidocaine produced the opposite effects on burst firing and terminal release. This selective modulation of the dynamic activity of mesolimbic dopamine neurons by the prefrontal cortex might be important in motivation, learning and schizophrenia.
利用电生理技术和体内伏安法，在水合氯醛麻醉的雄性大鼠中研究了内侧前额叶皮质（PFC）对中脑边缘多巴胺活性的影响。向PFC注射谷氨酸能选择性增加腹侧被盖区单个多巴胺能细胞的爆发式放电，并增强伏隔核中神经末梢的多巴胺释放。向PFC注射局部麻醉药利多卡因对爆发式放电和末梢释放产生相反的作用。前额叶皮质对中脑边缘多巴胺神经元动态活性的这种选择性调节可能在动机、学习和精神分裂症中起重要作用。
