Ader U, Muschalek V, Schneider M P
Faculty Number 9, Bergische Universität-GH-Wuppertal, Germany.
Chirality. 1993;5(7):554-9. doi: 10.1002/chir.530050712.
The enantiomeric purities of optically active intermediates for beta-adrenergic blocking agents prepared via enzyme-assisted processes can be determined rapidly and with high accuracy using HPLC on commercially available columns with chiral supports [Chiralcel OD, OB; Chiralpak OT(+)]. The dependence of the resolution parameters on the substitution pattern of both hydroxy compounds and their esters is reported.
通过酶辅助过程制备的β-肾上腺素能阻滞剂的光学活性中间体的对映体纯度，可以使用配备手性载体的市售色谱柱（Chiralcel OD、OB；Chiralpak OT(+)）通过高效液相色谱法快速且高精度地测定。报告了拆分参数对羟基化合物及其酯的取代模式的依赖性。
