Krumlauf R
Laboratory of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, UK.
Curr Opin Genet Dev. 1993 Aug;3(4):621-5. doi: 10.1016/0959-437x(93)90098-a.
Functional analysis of the genetic roles of the mammalian Hox homeobox family has not been facilitated by the analysis of disease-associated or classically derived mutant loci. However, an increasing number of mouse Hox mutations, generated by homologous recombination, have now demonstrated that the Hox genes are key components in regulating the patterning of axial structures.
