Aravich P F, Rieg T S, Ahmed I, Lauterio T J
Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk 23501.
Brain Res. 1993 May 28;612(1-2):180-9. doi: 10.1016/0006-8993(93)91659-g.
Anorexia nervosa is associated with vasopressin, oxytocin and serotonin abnormalities. Because of the relationship between exercise and anorexia nervosa, we explored the weight-loss syndrome produced by wheel running in food-deprived rats. Its effects on regional vasopressin and oxytocin concentrations were determined under basal conditions and following systemic fluoxetine. Weight-matched, exercised and unexercised rats served as controls. Fluoxetine caused abnormalities in suprachiasmatic vasopressin and dynorphin A content and in thymus oxytocin content that did not occur in weight-matched or exercised controls. No syndrome-specific anomalies occurred in the hypothalamo-neurohypophysial system or dorsal vagal complex (DVC). However, weight reduction and fluoxetine increased circulating vasopressin; moderate exercise caused fluoxetine-induced elevations in posterior pituitary vasopressin and oxytocin; and, unlike the other groups, fluoxetine increased DVC oxytocin in freely fed unexercised rats. It was concluded that syndrome-specific vasopressin and oxytocin abnormalities occur that are not secondary to weight loss or moderate exercise; that weight loss or fluoxetine increases circulating vasopressin; that moderate exercise alters neurohypophysial vasopressin and oxytocin content; and that weight loss or exercise inhibits a fluoxetine-stimulated increase in DVC oxytocin. Finally, it was argued that the fluoxetine abnormalities indicate possible serotonin dysfunction in the syndrome.
神经性厌食症与抗利尿激素、催产素和血清素异常有关。鉴于运动与神经性厌食症之间的关系，我们探究了食物匮乏的大鼠通过滚轮跑步产生的体重减轻综合征。在基础条件下以及全身性给予氟西汀后，测定了其对局部抗利尿激素和催产素浓度的影响。体重匹配的运动和未运动大鼠作为对照。氟西汀导致视交叉上核抗利尿激素和强啡肽A含量以及胸腺催产素含量出现异常，而在体重匹配或运动的对照中未出现这种情况。下丘脑 - 神经垂体系统或迷走背核（DVC）未出现综合征特异性异常。然而，体重减轻和氟西汀会增加循环抗利尿激素；适度运动导致氟西汀引起垂体后叶抗利尿激素和催产素升高；并且，与其他组不同，氟西汀会使自由进食的未运动大鼠的DVC催产素增加。得出的结论是，出现了综合征特异性的抗利尿激素和催产素异常，并非继发于体重减轻或适度运动；体重减轻或氟西汀会增加循环抗利尿激素；适度运动改变神经垂体抗利尿激素和催产素含量；体重减轻或运动抑制了氟西汀刺激的DVC催产素增加。最后，有人认为氟西汀异常表明该综合征可能存在血清素功能障碍。
