对利什曼原虫的天然和获得性抗性：埃塞俄比亚利什曼原虫对未接触过的个体的单核细胞的细胞激活是通过刺激自然杀伤（NK）细胞实现的。
Natural and acquired resistance to Leishmania: cellular activation by Leishmania aethiopica of mononuclear cells from unexposed individuals is through the stimulation of natural killer (NK) cells.
作者信息
Akuffo H, Maasho K, Howe R
机构信息
Department of Infectious Diseases, Karolinska Institute, Huddinge Hospital, Sweden.
出版信息
Clin Exp Immunol. 1993 Dec;94(3):516-21. doi: 10.1111/j.1365-2249.1993.tb08227.x.
Abstract
Cells from normal non-Leishmania-exposed individuals could respond in vitro by proliferation and interferon-gamma (IFN-gamma) production to Leishmania aethiopica stimulation. The main cell type that appeared to be activated following such stimulation was CD3-, CD16+/56+, i.e. NK cells. Of the few CD3+ cells responding, an involvement of CD8+ cells was evident in the absence of activation of CD4+ cells in normal individuals, while a different feature was observed when patients' cells were investigated. Cells from patients with L. aethiopica infection did not show this NK response, but rather the CD4+ cells were the prominent responding cells. No evidence of the involvement of superantigens or cells utilizing the gamma delta T cell receptor (gamma delta cells) in the response of unexposed individuals was noted.
摘要
来自未接触利什曼原虫的正常个体的细胞，在体外受到埃塞俄比亚利什曼原虫刺激后，可通过增殖和产生γ干扰素（IFN-γ）做出反应。受到这种刺激后似乎被激活的主要细胞类型是CD3-、CD16+/56+，即自然杀伤细胞（NK细胞）。在正常个体中，少数做出反应的CD3+细胞中，CD8+细胞明显参与其中，而CD4+细胞未被激活；但在研究患者细胞时观察到了不同的特征。埃塞俄比亚利什曼原虫感染患者的细胞未表现出这种NK反应，而是CD4+细胞成为主要的反应细胞。未观察到超抗原或利用γδT细胞受体的细胞（γδ细胞）参与未接触个体反应的证据。
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