Lerner A B, Moellmann G
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510-8059.
Acta Derm Venereol. 1993 Aug;73(4):241-50. doi: 10.2340/0001555573241250.
Two unusual patients with metastatic melanoma are presented. One had generalized melanosis, and the other a rapid induction of multiple small pigmented lesions within a day of exposure to the sun. From a variety of clinical observations on these 2 patients and ones reported in the literature, and from recent advances in basic biomedical knowledge, we conclude that in both conditions the anomalous presence of growth factors that stimulate the proliferation and melanogenic differentiation of normal and malignant melanocytes played a major role in producing the clinical events.
本文报告了两名患有转移性黑色素瘤的特殊患者。一名患者有全身黑变病，另一名患者在暴露于阳光下一天内迅速出现多个小色素沉着病变。基于对这两名患者的各种临床观察以及文献报道，再结合基础生物医学知识的最新进展，我们得出结论：在这两种情况下，刺激正常和恶性黑素细胞增殖及黑素生成分化的生长因子异常存在，在导致临床症状方面起了主要作用。
