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[使用聚合酶链反应分析居住在莫斯科的无关俄罗斯个体中四个高变串联重复序列的等位基因分布]

[Analysis of the distribution of alleles of four hypervariable tandem repeats among unrelated Russian individuals living in Moscow, using the polymerase chain reaction].

作者信息

Chistiakov D A, Gavrilov D K, Ovchinnikov I V, Nosikov V V

出版信息

Mol Biol (Mosk). 1993 Nov-Dec;27(6):1304-14.

PMID:7904327
Abstract

Allele frequencies of four VNTR regions (loci D1S80, D17S30, APOB and IGHJ) were determined in 120 unrelated Russian individuals living in Moscow. The high level of length polymorphism was discovered among alleles of these VNTRs. The genotype distribution of these hypervariable regions was established on the basis of experimental data. The comparative analysis showed the likeness between the allele distributions of these VNTRs among Russians and other groups of Caucasians living in Europe and North America.

摘要

在居住于莫斯科的120名无血缘关系的俄罗斯个体中,测定了四个VNTR区域(基因座D1S80、D17S30、APOB和IGHJ)的等位基因频率。在这些VNTR的等位基因中发现了高度的长度多态性。基于实验数据确定了这些高变区的基因型分布。比较分析表明,这些VNTR在俄罗斯人与居住在欧洲和北美的其他高加索人群体中的等位基因分布相似。

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