Luttropp H H, Romner B, Perhag L, Eskilsson J, Fredriksen S, Werner O
Department of Anaesthesia, University Hospital, Lund, Sweden.
Anaesthesia. 1993 Dec;48(12):1045-9. doi: 10.1111/j.1365-2044.1993.tb07522.x.
The effects of xenon anaesthesia on myocardial function and cerebral blood flow velocities were investigated with transoesophageal echocardiography and transcranial Doppler sonography. Seventeen ASA 1 patients undergoing open cholecystectomy (n = 16) or abdominal hysterectomy (n = 1) were studied. Anaesthesia with 65% xenon in oxygen was induced by ventilating the lungs through a circle system with minimal fresh gas flow. The echocardiographically obtained mean (SD) fractional area change in a short axis view of the left ventricle at the level of the papillary muscles was 65 (10)% (n = 14) before xenon. There was no significant change after 5, 10 and 15 min of xenon anaesthesia. Cerebral blood flow velocities were unchanged during the first 5 min of xenon anaesthesia, but were significantly increased in the left and right middle, and the right anterior, cerebral arteries after 15 and 30 min (n = 16) (p < 0.05). In conclusion, xenon anaesthesia had no adverse effect on myocardial function, but probably increased cerebral flood flow.
采用经食管超声心动图和经颅多普勒超声检查，研究了氙气麻醉对心肌功能和脑血流速度的影响。研究对象为17例美国麻醉医师协会（ASA）分级为1级、正在接受开腹胆囊切除术（n = 16）或腹式子宫切除术（n = 1）的患者。通过环路系统以最小新鲜气流对肺进行通气，诱导65%氙气与氧气混合的麻醉。在注入氙气前，经超声心动图测得在乳头肌水平左心室短轴视图的平均（标准差）面积变化分数为65（10）%（n = 14）。氙气麻醉5、10和15分钟后，该指标无显著变化。在氙气麻醉的前5分钟内，脑血流速度未发生改变，但在15和30分钟后，左、右大脑中动脉以及右大脑前动脉的血流速度显著增加（n = 16）（p < 0.05）。总之，氙气麻醉对心肌功能无不良影响，但可能会增加脑血流量。
