Sack M N, Rader D J, Cannon R O
Georgetown University Hospital, Washington, DC.
Lancet. 1994 Jan 29;343(8892):269-70. doi: 10.1016/s0140-6736(94)91117-7.
Oxidative modification of low-density lipoprotein (LDL) may be atherogenic. We studied the time of onset of LDL oxidation (lag) in 18 postmenopausal women before and after intraarterial infusion of 17 beta-oestradiol, after 3 weeks' patch administration in 12 of these women, and 1 month after discontinuation in 10. The lag increased from baseline after acute infusion (from 134 [SD41] to 167 [36] min, p = 0.01) and after the patch (132 [31] to 178 [45] min, p = 0.009). After discontinuation of oestradiol, the lag returned to baseline. This study shows an antioxidant effect of physiological levels of 17 beta-oestradiol, which may contribute to an anti-atherogenic action.
低密度脂蛋白（LDL）的氧化修饰可能具有致动脉粥样硬化作用。我们研究了18名绝经后女性在动脉内输注17β-雌二醇前后、其中12名女性进行3周贴片给药后以及10名女性停药1个月后的LDL氧化起始时间（延迟时间）。急性输注后（从134[标准差41]分钟增至167[36]分钟，p = 0.01）以及贴片给药后（从132[31]分钟增至178[45]分钟，p = 0.009），延迟时间均从基线水平增加。停用雌二醇后，延迟时间恢复至基线水平。本研究显示生理水平的17β-雌二醇具有抗氧化作用，这可能有助于其抗动脉粥样硬化作用。
