Aleksandrov A N, Ovsiannikov V I
Biull Eksp Biol Med. 1993 Oct;116(10):341-3.
Experiments were performed on unanaesthetized rabbits. It has been shown that beta-adrenergic stimulation by isoprenaline can lead to decreasing as well as increasing of spike activity of the ileum. Pretreatment with propranolol completely prevented both effects of isoprenaline. Administration of isoprenaline both during M-cholinergic and N-cholinergic blockades resulted in decreased spike activity alone. These results suggest that isoprenaline-induced increase in spike activity is mediated by excitatory beta-adrenoceptors localized on the presynaptic cholinergic interneurons of the enteric nervous system.
在未麻醉的兔子身上进行了实验。结果表明，异丙肾上腺素对β-肾上腺素能的刺激可导致回肠锋电位活动的降低和增加。用普萘洛尔预处理可完全阻断异丙肾上腺素的这两种作用。在M胆碱能和N胆碱能阻断期间给予异丙肾上腺素，均单独导致锋电位活动降低。这些结果表明，异丙肾上腺素诱导的锋电位活动增加是由位于肠神经系统突触前胆碱能中间神经元上的兴奋性β-肾上腺素能受体介导的。
