Marchant A, Devière J, Byl B, De Groote D, Vincent J L, Goldman M
Department of Immunology, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
Lancet. 1994 Mar 19;343(8899):707-8. doi: 10.1016/s0140-6736(94)91584-9.
Interleukin-10 is produced during incubation of human whole blood with bacterial lipopolysaccharide (LPS) and down-regulates tumour necrosis factor-alpha production in this in-vitro model of endotoxaemia. 39 out of 69 (57%) patients with gram-negative (n = 25) or gram-positive septicaemia (n = 44) had increased plasma interleukin-10 (range 12-2740 pg/mL), whereas interleukin-10 was undetectable in 29 out of 33 control patients without infection and in 20 healthy volunteers. Patients with septic shock (n = 21) had higher interleukin-10 (main 58 pg/mL) than septicaemic patients without shock (11 pg/mL, p < 0.001). We conclude that interleukin-10 is produced during sepsis and might be involved in the control of the inflammatory response induced by bacterial products.
在人全血与细菌脂多糖（LPS）孵育过程中会产生白细胞介素-10，在这种内毒素血症的体外模型中，白细胞介素-10会下调肿瘤坏死因子-α的产生。69例革兰氏阴性（n = 25）或革兰氏阳性败血症（n = 44）患者中有39例（57%）血浆白细胞介素-10升高（范围为12 - 2740 pg/mL），而在33例无感染的对照患者中的29例以及20名健康志愿者中未检测到白细胞介素-10。感染性休克患者（n = 21）的白细胞介素-10水平（中位数58 pg/mL）高于无休克的败血症患者（11 pg/mL，p < 0.001）。我们得出结论，败血症期间会产生白细胞介素-10，其可能参与控制由细菌产物诱导的炎症反应。
