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人类肺癌的遗传易感性。

Genetic predisposition to human lung cancer.

作者信息

Heighway J, Thatcher N, Cerny T, Hasleton P S

出版信息

Br J Cancer. 1986 Apr;53(4):453-7. doi: 10.1038/bjc.1986.72.

DOI:10.1038/bjc.1986.72
PMID:3011049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2001439/
Abstract

The influence of polymorphic variants of the human c-Ha-ras gene on predisposition to lung cancer has been investigated. The human c-Ha-ras gene has been shown to reside on a polymorphic BamH1 restriction fragment. This restriction fragment length polymorphism (RFLP) results from variation in the size of a region of repetitive DNA 3' to the gene. An attempt has been made to characterise and compare the c-Ha-ras RFLP's in a normal population and in a group of cancer patients. DNA was extracted from the white blood cells of 101 normal donors and four common Ha-ras alleles identified, with occasional rare alleles of various sizes. The allele frequencies were examined in 132 lung cancer patients, comprising 66 individuals with small cell carcinoma of the lung (SCCL) and 66 with non-small cell carcinoma of the lung (non-SCCL). An abnormal allele distribution was found in individuals with non-SCCL compared to both control and SCCL values suggesting a degree of genetic pre-position to non-SCCL. In addition, analysis of the Ha-ras RFLP's in solid samples inferred a deletion of material from the short arm of chromosome 11 in two of 16 informative samples.

摘要

人类c-Ha-ras基因多态性变体对肺癌易感性的影响已得到研究。已证明人类c-Ha-ras基因位于一个多态性BamH1限制性片段上。这种限制性片段长度多态性（RFLP）是由基因3'端重复DNA区域大小的变化引起的。已尝试对正常人群和一组癌症患者中的c-Ha-ras RFLP进行表征和比较。从101名正常供体的白细胞中提取DNA，并鉴定出四个常见的Ha-ras等位基因，偶尔还有各种大小的罕见等位基因。在132名肺癌患者中检查了等位基因频率，其中包括66名肺小细胞癌（SCCL）患者和66名肺非小细胞癌（非SCCL）患者。与对照组和SCCL值相比，在非SCCL患者中发现了异常的等位基因分布，这表明非SCCL存在一定程度的遗传易感性。此外，对固体样本中Ha-ras RFLP的分析推断，在16个信息丰富的样本中有两个样本的11号染色体短臂存在物质缺失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5915/2001439/0ae512ab859c/brjcancer00528-0007-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5915/2001439/9c909fb3e1d9/brjcancer00528-0005-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5915/2001439/df3d959ad7a9/brjcancer00528-0005-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5915/2001439/0ae512ab859c/brjcancer00528-0007-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5915/2001439/9c909fb3e1d9/brjcancer00528-0005-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5915/2001439/df3d959ad7a9/brjcancer00528-0005-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5915/2001439/0ae512ab859c/brjcancer00528-0007-a.jpg

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本文引用的文献

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