Brown K E, Green S W, Antunez de Mayolo J, Bellanti J A, Smith S D, Smith T J, Young N S
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.
Lancet. 1994 Apr 9;343(8902):895-6. doi: 10.1016/s0140-6736(94)90011-6.
We report three children with congenital anaemia after intrauterine infection with B19 parvovirus. All the fetuses developed hydrops fetalis that was treated by blood transfusion. After delivery the infants had hypogammaglobulinaemia. In all three, sera lacked B19 but viral DNA was found in bone marrow. All were treated with immunoglobulin. One child died and B19 was found in various tissues. In the other two cases, virus could no longer be detected after therapy but the patients remain persistently anaemic. Persistent B19 infection should be suspected in infants with congenital red-cell aplasia.
我们报告了3例因宫内感染B19细小病毒而患先天性贫血的儿童。所有胎儿均出现胎儿水肿，并接受了输血治疗。出生后，婴儿出现低丙种球蛋白血症。在这3例患儿中，血清中均未检测到B19，但在骨髓中发现了病毒DNA。所有患儿均接受了免疫球蛋白治疗。1例患儿死亡，在其各种组织中均发现了B19。在另外2例患儿中，治疗后病毒检测不到，但患者仍持续贫血。对于患有先天性红细胞再生障碍的婴儿，应怀疑存在持续性B19感染。
