Daugbjerg P S, Bach-Mortensen N, Osterballe O
Allergy. 1984 Oct;39(7):535-41. doi: 10.1111/j.1398-9995.1984.tb00875.x.
Thirty-two children and two adults with chronic atopic dermatitis related to food allergy entered this double-blind crossover study comparing oral sodium cromoglycate (200-1600 mg/24 h) with placebo. Each treatment period comprised 6 weeks: 4 weeks on elimination diet, and 2 weeks on a normal, i.e. unrestricted diet. The diagnosis of food allergy was made after clinical improvement with elimination diet and relapse after challenge. Overall analysis of skin symptoms evaluated by means of clinical assessments and diary cards, opinions of treatment, and use of concomitant medication gave no evidence of any difference between sodium cromoglycate and placebo. Unusual symptoms were reported by 18 patients. In one case the patient was withdrawn during the sodium cromoglycate period because of side effects. The majority of symptoms with both treatments were stomach problems. Overall analysis of the laboratory data gave no significant differences between treatments.
32名患有与食物过敏相关的慢性特应性皮炎的儿童和2名成人参与了这项双盲交叉研究，该研究比较了口服色甘酸钠（200 - 1600毫克/24小时）与安慰剂的效果。每个治疗阶段为期6周：4周进行排除饮食，2周进行正常饮食，即无限制饮食。食物过敏的诊断是在排除饮食后临床症状改善且激发试验后复发时做出的。通过临床评估和日记卡对皮肤症状进行的总体分析、对治疗的看法以及伴随药物的使用情况均未显示色甘酸钠和安慰剂之间存在任何差异。18名患者报告了异常症状。有1例患者在服用色甘酸钠期间因副作用退出研究。两种治疗方法导致的大多数症状都是胃部问题。对实验室数据的总体分析表明，各治疗组之间无显著差异。
