Amanullah A
Am J Dis Child. 1976 Nov;130(11):1274-80. doi: 10.1001/archpedi.1976.02120120108023.
This article discusses the production, transport, and excretion of bilirubin in the newborn period. The causes, significance, and treatment of unconjugated and conjugated hyperbilirubinemia are different; and because this is so, it is important to review the main causes and management of unconjugated hyperbilirubinemia. Conjugated hyperbilirubinemia in the newborn period could be either due to hepatocellular dysfunction or extrahepatic biliary obstruction. There are several recent advances in early differentiation and management of these two entities.
本文讨论了新生儿期胆红素的生成、转运及排泄。未结合型和结合型高胆红素血症的病因、意义及治疗方法有所不同;正因如此,回顾未结合型高胆红素血症的主要病因及处理方法很重要。新生儿期的结合型高胆红素血症可能是由于肝细胞功能障碍或肝外胆管梗阻所致。在这两种情况的早期鉴别及处理方面,近期有多项进展。