Matas A J, Hertel B F, Rosai J, Simmoms R L, Najarian J S
Am J Med. 1976 Nov;61(5):716-20. doi: 10.1016/0002-9343(76)90151-0.
Malignant lymphoma developed in two patients after renal transplantation. In both, the central nervous system was involved. Histologic study of the tumors showed that they were composed of a monomorphous proliferation of cells characterized by a large vesicular nucleus, prominent basophilic nucleolus and strongly pyroninophilic cytoplasm. The tumors thus would be classified as "diffuse large lymphoid lymphomas with pyroninophilia" or "immunoblastic sarcomas" as described in the literature. Tumor cells resembled cells observed in the paracortex of antigenically stimulated lymph nodes, cells from malignant lymphomas in mice that were antigenically stimulated and from malignant lymphomas in patients with immunodeficiency diseases or autoimmune disorders. The distinctive morphologic features of the tumors in the transplant recipients described provide further evidence that long-term antigenic stimulation may be important in their pathogenesis.
两名肾移植患者发生了恶性淋巴瘤。两人的中枢神经系统均受累。肿瘤的组织学研究表明，它们由细胞的单形性增殖组成，其特征为大泡状核、突出的嗜碱性核仁以及强嗜派洛宁性细胞质。因此，这些肿瘤将被归类为文献中所述的“伴有嗜派洛宁性的弥漫性大淋巴细胞淋巴瘤”或“免疫母细胞肉瘤”。肿瘤细胞类似于在抗原刺激的淋巴结副皮质区观察到的细胞、抗原刺激的小鼠恶性淋巴瘤细胞以及免疫缺陷疾病或自身免疫性疾病患者的恶性淋巴瘤细胞。所描述的移植受者肿瘤独特的形态学特征进一步证明长期抗原刺激在其发病机制中可能很重要。
