Modai I, Malmgren R, Wetterberg L, Eneroth P, Valevski A, Asberg M
Gehah Psychiatric Hospital, Petah Tiqva, Israel.
Psychiatry Res. 1992 Aug;43(2):161-6. doi: 10.1016/0165-1781(92)90130-u.
Blood levels of melatonin, serotonin, cortisol, prolactin, and serotonin uptake by platelets were measured at 08:00, 14:00, 20:00, 02:00, and 08:00 hours in 10 healthy men who ranged in age from 27 to 35 years. The Km values of serotonin active transport by platelets were significantly correlated with melatonin blood levels. There were no other significant correlations. The secretion of steroid hormones and prolactin showed an increase at 02:00 hours; levels of prolactin decreased at 08:00 hours, but steroid levels continued to rise. This finding suggests either a direct effect of melatonin on serotonin active transport or the influence of the suprachiasmatic nucleus on serotonin uptake by platelets. It is also possible that there is a simultaneous decrease in serotonin uptake and decline from peak levels of melatonin due to the rise in steroid secretion.
在10名年龄在27至35岁之间的健康男性中，于08:00、14:00、20:00、02:00和08:00测量了褪黑素、血清素、皮质醇、催乳素的血液水平以及血小板对血清素的摄取。血小板血清素主动转运的Km值与褪黑素血液水平显著相关。不存在其他显著相关性。类固醇激素和催乳素的分泌在02:00时增加；催乳素水平在08:00时下降，但类固醇水平持续上升。这一发现表明褪黑素对血清素主动转运有直接作用，或者视交叉上核对血小板摄取血清素有影响。也有可能由于类固醇分泌增加，血清素摄取同时减少且褪黑素水平从峰值下降。
