Mählck C G, Jonsson H, Lenner P
Institution of Obstetrics/Gynecology, University of Umeå, Sweden.
Int J Gynaecol Obstet. 1994 Mar;44(3):267-72. doi: 10.1016/0020-7292(94)90177-5.
Age-adjusted incidence of cervical carcinoma has fallen dramatically in Sweden in recent decades. This investigation is an attempt to evaluate the effectiveness of the gynecologic Pap smear screening program in terms of reduction of mortality from cervical cancer.
Cervical cancer mortality trends in relation to age, calendar period, county and degree of screening activities in the population were analyzed. Multiplicative Poisson regression models were utilized. The reduction of mortality was attributed to the activities of cervical screening.
The analysis gave a calculated 53% reduction in cervical cancer mortality (95% confidence limits 23-72%), attributable to screening.
The study supports the hypothesis that gynecological Pap smear screening has had an important impact on the reduction in cervical cancer mortality.
近几十年来，瑞典宫颈癌的年龄调整发病率大幅下降。本研究旨在评估妇科巴氏涂片筛查计划在降低宫颈癌死亡率方面的有效性。
分析了宫颈癌死亡率与年龄、日历时间、县以及人群筛查活动程度之间的趋势。采用了乘法泊松回归模型。死亡率的降低归因于宫颈筛查活动。
分析得出，归因于筛查的宫颈癌死亡率计算降低了53%（95%置信区间为23%-72%）。
该研究支持以下假设，即妇科巴氏涂片筛查对降低宫颈癌死亡率产生了重要影响。
