一氧化氮：介质、杀手与药物。

Nitric oxide: mediator, murderer, and medicine.

作者信息

Anggård E

机构信息

William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, UK.

出版信息

Lancet. 1994 May 14;343(8907):1199-206. doi: 10.1016/s0140-6736(94)92405-8.

DOI:10.1016/s0140-6736(94)92405-8

PMID:7909873

Abstract

In the past ten years several research fields have converged to show that the tiny molecule nitric oxide (NO), a reactive gas, functions both as a signalling molecule in endothelial and nerve cells and as a killer molecule by activated immune cells--and it can be used as a new medicine by inhalation. This article reviews the biology of this remarkable molecule and discusses the implications for clinical medicine.

摘要

在过去十年中，多个研究领域的成果汇聚在一起，表明小分子一氧化氮（NO）这种活性气体，在内皮细胞和神经细胞中作为信号分子发挥作用，同时在活化的免疫细胞中作为杀伤分子——并且它可以通过吸入用作一种新药。本文综述了这种非凡分子的生物学特性，并讨论了其对临床医学的意义。